TonB?dependent transporters in the Bacteroidetes: Unique domain structures and potential functions

The human gut microbiota endows the host with a wealth of metabolic functions central to health, one which is degradation and fermentation complex carbohydrates. Bacteroidetes are dominant bacterial phyla this community possess an expanded capacity for glycan utilization. This mediated via coordinated expression discrete polysaccharide utilization loci (PUL) that invariantly encode TonB-dependent transporter (SusC) works glycan-capturing lipoprotein (SusD). More broadly within Gram-negative bacteria, transporters (TBDTs) deployed uptake not only sugars, but also more often essential nutrients such as iron vitamins. Here, we provide comprehensive look at repertoire TBDTs found in model symbiont Bacteroides thetaiotaomicron range predicted functional domains associated these SusD proteins both glycans other nutrients. atlas B. reveals there least three distinct subtypes encoded its genome presumably regulated different ways tune nutrient uptake.